Interferon-beta and interferon-gamma synergistically inhibit the replication of severe acute respiratory syndrome-associated coronavirus (SARS-CoV).
Identifieur interne : 005278 ( Main/Exploration ); précédent : 005277; suivant : 005279Interferon-beta and interferon-gamma synergistically inhibit the replication of severe acute respiratory syndrome-associated coronavirus (SARS-CoV).
Auteurs : Bruno Sainz [États-Unis] ; Eric C. Mossel ; C J Peters ; Robert F. GarrySource :
- Virology [ 0042-6822 ] ; 2004.
Descripteurs français
- KwdFr :
- MESH :
- pharmacologie : Interféron bêta, Interféron de type I, Interféron gamma.
- physiologie : Virus du SRAS.
- Animaux, Cellules Vero, Effet cytopathogène viral, Humains, Protéines recombinantes, Réplication virale, Souris, Virus du SRAS.
English descriptors
- KwdEn :
- Animals, Chlorocebus aethiops, Cytopathogenic Effect, Viral (drug effects), Humans, Interferon Type I (pharmacology), Interferon-beta (pharmacology), Interferon-gamma (pharmacology), L Cells, Mice, Recombinant Proteins, SARS Virus (drug effects), SARS Virus (physiology), Vero Cells, Virus Replication (drug effects).
- MESH :
- chemical , pharmacology : Interferon Type I, Interferon-beta, Interferon-gamma.
- drug effects : Cytopathogenic Effect, Viral, SARS Virus, Virus Replication.
- physiology : SARS Virus.
- Animals, Chlorocebus aethiops, Humans, L Cells, Mice, Recombinant Proteins, Vero Cells.
Abstract
Recent studies have shown that interferon-gamma (IFN-gamma) synergizes with IFN-alpha/beta to inhibit the replication of both RNA and DNA viruses. We investigated the effects of IFNs on the replication of two strains of severe acute respiratory syndrome-associated coronavirus (SARS-CoV). While treatment of Vero E6 cells with 100 U/ml of either IFN-beta or IFN-gamma marginally reduced viral replication, treatment with both IFN-beta and IFN-gamma inhibited SARS-CoV plaque formation by 30-fold and replication by 3000-fold at 24 h and by > 1 x 10(5)-fold at 48 and 72 h post-infection. These studies suggest that combination IFN treatment warrants further investigation as a treatment for SARS.
DOI: 10.1016/j.virol.2004.08.011
PubMed: 15476870
Affiliations:
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Le document en format XML
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Mossel</name></author><author><name sortKey="Peters, C J" sort="Peters, C J" uniqKey="Peters C" first="C J" last="Peters">C J Peters</name></author><author><name sortKey="Garry, Robert F" sort="Garry, Robert F" uniqKey="Garry R" first="Robert F" last="Garry">Robert F. 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Mossel</name></author><author><name sortKey="Peters, C J" sort="Peters, C J" uniqKey="Peters C" first="C J" last="Peters">C J Peters</name></author><author><name sortKey="Garry, Robert F" sort="Garry, Robert F" uniqKey="Garry R" first="Robert F" last="Garry">Robert F. Garry</name></author></analytic><series><title level="j">Virology</title><idno type="ISSN">0042-6822</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Chlorocebus aethiops</term><term>Cytopathogenic Effect, Viral (drug effects)</term><term>Humans</term><term>Interferon Type I (pharmacology)</term><term>Interferon-beta (pharmacology)</term><term>Interferon-gamma (pharmacology)</term><term>L Cells</term><term>Mice</term><term>Recombinant Proteins</term><term>SARS Virus (drug effects)</term><term>SARS Virus (physiology)</term><term>Vero Cells</term><term>Virus Replication (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules Vero</term><term>Effet cytopathogène viral ()</term><term>Humains</term><term>Interféron bêta (pharmacologie)</term><term>Interféron de type I (pharmacologie)</term><term>Interféron gamma (pharmacologie)</term><term>Protéines recombinantes</term><term>Réplication virale ()</term><term>Souris</term><term>Virus du SRAS ()</term><term>Virus du SRAS (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Interferon Type I</term><term>Interferon-beta</term><term>Interferon-gamma</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cytopathogenic Effect, Viral</term><term>SARS Virus</term><term>Virus Replication</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Interféron bêta</term><term>Interféron de type I</term><term>Interféron gamma</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Chlorocebus aethiops</term><term>Humans</term><term>L Cells</term><term>Mice</term><term>Recombinant Proteins</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules Vero</term><term>Effet cytopathogène viral</term><term>Humains</term><term>Protéines recombinantes</term><term>Réplication virale</term><term>Souris</term><term>Virus du SRAS</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent studies have shown that interferon-gamma (IFN-gamma) synergizes with IFN-alpha/beta to inhibit the replication of both RNA and DNA viruses. We investigated the effects of IFNs on the replication of two strains of severe acute respiratory syndrome-associated coronavirus (SARS-CoV). While treatment of Vero E6 cells with 100 U/ml of either IFN-beta or IFN-gamma marginally reduced viral replication, treatment with both IFN-beta and IFN-gamma inhibited SARS-CoV plaque formation by 30-fold and replication by 3000-fold at 24 h and by > 1 x 10(5)-fold at 48 and 72 h post-infection. These studies suggest that combination IFN treatment warrants further investigation as a treatment for SARS.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Louisiane</li></region></list><tree><noCountry><name sortKey="Garry, Robert F" sort="Garry, Robert F" uniqKey="Garry R" first="Robert F" last="Garry">Robert F. Garry</name><name sortKey="Mossel, Eric C" sort="Mossel, Eric C" uniqKey="Mossel E" first="Eric C" last="Mossel">Eric C. Mossel</name><name sortKey="Peters, C J" sort="Peters, C J" uniqKey="Peters C" first="C J" last="Peters">C J Peters</name></noCountry><country name="États-Unis"><region name="Louisiane"><name sortKey="Sainz, Bruno" sort="Sainz, Bruno" uniqKey="Sainz B" first="Bruno" last="Sainz">Bruno Sainz</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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